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pentobarbital will lessen the extent or effect of lefamulin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Keep away from coadministration of lefamulin with strong or average CYP3A inducers Except the benefit outweighs pitfalls. Keep an eye on for diminished efficacy.Observe Carefully (one)pentobar